Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer-related deaths worldwide due to high recurrence rates after curative treatment and being frequently diagnosed at an advanced stage.Immune-checkpoint inhibition (ICPI) has yielded impressive clinical successes in a variety of solid cancers, however results in treatment of HCC have
Laboratory Investigation of Geobag Revetment Performance in Rivers
Geobag (sand-filled geotextile bags) revetments have recently emerged as long-term riverbank protection measures in developing countries; however, their performance is still not well understood.The hydraulic stability of geobag revetments Liquid Lipstick used for riverbank protection has been studied within an extensive laboratory programme to impr
A Review of Activity-based Disaggregate Travel Demand Models
This paper reviews the literature on disaggregated travel demand models from a Skin Cream choice perspective, focusing on activity-based models (ABMs) and synthetic population generators as example approaches to capture these choice dimensions.We discuss the links between these models and elaborate on their integration, emphasizing how advanced pop
The intersection of the extrinsic hedgehog and WNT/wingless signals with the intrinsic Hox code underpins branching pattern and tube shape diversity in the drosophila airways.
The tubular networks of the Drosophila respiratory system and our vasculature show distinct branching Locking Cable patterns and tube shapes in different body regions.These local variations are crucial for organ function and organismal fitness.Organotypic patterns and tube geometries in branched networks are typically controlled by variations of ex
Novel SPTBN2 gene mutation and first intragenic deletion in early onset spinocerebellar ataxia type 5
Abstract In the present study, we describe two novel cases of Locking Cable SCA5 with early onset.The first one, carrying a novel heterozygous de novo missense mutation in SPTBN2 gene, showed a striking very severe cerebellar atrophy and reduction of volume of the pons at a very young age (16 months).The latter, carrying the first de novo intrageni